Laboratory diagnosis of Clostridium difficile disease
نویسندگان
چکیده
منابع مشابه
Current knowledge on the laboratory diagnosis of Clostridium difficile infection
Clostridium difficile (C. difficile) is a spore-forming, toxin-producing, gram-positive anaerobic bacterium that is the principal etiologic agent of antibiotic-associated diarrhea. Infection with C. difficile (CDI) is characterized by diarrhea in clinical syndromes that vary from self-limited to mild or severe. Since its initial recognition as the causative agent of pseudomembranous colitis, C....
متن کاملDiagnosis of Clostridium difficile infection.
TO THE EDITOR—Despite our long-standing interest in earlier tests for Clostridium difficile toxin [1], we believe that polymerase chain reaction (PCR) technology should simply replace other algorithms for the diagnosis of C. difficile infection, as recently outlined in Clinical Infectious Diseases by Kufelnicka and Kirn [2]. We studied 122 consecutive specimens submitted for C. difficile testin...
متن کاملClostridium difficile associated disease
Direct gas-liquid chromatography of faecal specimens with isocaproic acid as a marker was used for the rapid diagnosis of Clostridium difficile associated diarrhoeal diseases. Ninety stools were examined and results were compared with conventional culture on selective medium and cytotoxin assay in tissue culture. Using a combined analysis of isocaproic acid and butyric acid peak heights we defi...
متن کاملTitle: CLOSTRIDIUM DIFFICILE INFECTION LABORATORY CASE DEFINITION
1.1 Condition: Clostridium difficile infection (CDI). A diagnosis of CDI implies: a) laboratory detection of C. difficile toxins and/or toxigenic C. difficile in faeces, rectal swab or bowel contents PLUS b) relevant clinical manifestations: diarrhoea (usually defined as 3 or more loose stools in a 24 hour period) or, less commonly, ileus, toxic megacolon or pseudomembranous colitis (identified...
متن کاملClostridium difficile disease: Diagnosis, pathogenesis, and treatment update.
Clostridium difficile infections are the leading cause of health care-associated infectious diarrhea, posing a significant risk for both medical and surgical patients. Because of the significant morbidity and mortality associated with C difficile infections, knowledge of the epidemiology of C difficile in combination with a high index of suspicion and susceptible patient populations (including ...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2001
ISSN: 1198-743X
DOI: 10.1046/j.1198-743x.2001.00294.x